ABSTRACT: Heel pain is one of the common musculoskeletal conditions. There are many physical therapeutic modalities including iontophoresis available for patients with heel pain. Acetate iontophoresis is commonly used for relieving heel pain. Salicylate iontophoresis is known for its analgesic and anti-inflammatory effect. However there is a paucity of data on effectiveness of sodium salicylate iontophoresis on heel pain. The purpose of this study was to evaluate the effectiveness of salicylate iontophoresis on heel pain and to compare it with acetate iontophoresis. Sixty patients with heel pain aged 25-40 years were included in the study and were randomly divided into 2 groups containing 30 patients each. Patients in group A (control group) were treated with acetic acid iontophoresis and in group B (experimental group) were treated with sodium salicylate iontophoresis. All patients received 6 sessions of iontophoresis over the period of 2 weeks. Pain on VAS and TUG test was assessed pre intervention, at the end of 2 weeks and 4 weeks. On statistical analysis, group B patients had statistically significant improvement in pain on VAS (p<0.001) as compared to group A. There was no statistically significant difference in TUGT (p<0.001) between the two groups. This study concludes that sodium salicylate iontophoresis was more effective in reducing heel pain. Keywords: Iontophoresis,sodium salicylate,acetic acid,heel pain,VAS,TUG test --------------------------------------------------------------------------------------------------------------------------------------